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Issue title: ARO Meeting 2001
Article type: Research Article
Authors: Rubinstein, J.T.a | Santina, C.C. Dellab
Affiliations: [a] Departments of Otolaryngology, Physiology & Biophysics and Biomedical Engineering, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. E-mail: jay-rubinstein@uiowa.edu | [b] Departments of Otolaryngology – Head & Neck Surgery and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA
Abstract: Physiologic properties of primary vestibular neurons are compared and contrasted with properties of primary auditory neurons. The differences and similarities suggest possible coding strategies for a vestibular implant. The degree of spike rate variability, or coefficient of variation (CV), is a prominent physiological property of vestibular neurons with undetermined functional significance. At the very least, CV is highly correlated with threshold to electrical stimulation in the intact vestibular labyrinth. If CV is also important for vestibular coding, then electrical stimulation strategies should be designed to restore relatively physiologic patterns of CV. Simulations using a stochastic model of primary afferent vestibular neurons reveal that this should be possible using combinations of low and high-rate pulsatile stimulation. They also demonstrate that differences in the number and independence of synaptic inputs can significantly affect CV.
Keywords: electrical stimulation, vestibular nerve, stochastic simulation
DOI: 10.3233/VES-2003-122-302
Journal: Journal of Vestibular Research, vol. 12, no. 2-3, pp. 69-76, 2003
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