Hematological and biochemical profiles in children with cerebral palsy: A cross-sectional study

Issue title: Cerebral Palsy

Guest editors: Rachel Byrne, Deborah Gaebler-Spira, Michael Green and Heakyung Kim

Article type: Research Article

Authors: Khandelwal, Rohit^{a; *} | Manjunath, Vivek Vankalapati^a | Mehta, Leeni^b | Mangajjera, Shivalingappa Bussenahalli^a

Affiliations: [a] Department of Paediatrics, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India | [b] Department of Internal Medicine, Apollo Group of Hospitals, Bangalore, India

Correspondence: [*] Corresponding author: Dr. Rohit Khandelwal, Professor, Department Of Paediatrics, Vydehi Institute Of Medical Sciences And Research Centre, No.82, E.P.I.P Area, Whitefield, Bangalore, Karnataka, India. E-mail: doc.rohitkhandelwal@gmail.com.

Abstract: PURPOSE:Cerebral palsy is a common pediatric neurological problem that has multiple comorbidities, including nutritional issues. Hematological and biochemical parameters significantly affect the health status of patients with cerebral palsy, and till now very few studies have analyzed these parameters. This study aimed to describe the hematological and biochemical parameters of children diagnosed with cerebral palsy. METHODS:This four-year observational study included children with cerebral palsy who were admitted to the Department of Pediatrics of a medical college teaching hospital.Hemoglobin, platelet count, white blood count (WBC), red blood cells (RBCs), packed cell volume, RBC indices, and biochemical parameters (urea, creatinine, total bilirubin, total protein, albumin, globulin, aspartate transaminase, alanine transaminase, electrolytes, calcium and alkaline phosphatase) were noted and values (mean, standard deviation, and interquartile range) presented. Age and gender-based analyses were performed. RESULTS:The average hemoglobin level was 11.48 mg/dl, platelet count was 301.24×109/L, and WBC count was 11.13 109/L. Anemia was observed more commonly in males younger than nine years of age. Of 282 patients, 14 (4.96%) had a platelet count of less than 150×109/L. Abnormal alkaline phosphatase levels were observed more commonly in patients who were younger than nine years of age and in females more than males, and the difference was statistically significant. Protein levels and calcium levels were similar between both age groups. CONCLUSION:Anemia was more common in younger patients and males with cerebral palsy. Abnormal bone turnover markers (alkaline phosphatase) were more common in young patients and females with cerebral palsy. Understanding the differential effect of age and gender on various investigational parameters will help improve care of children with cerebral palsy by initiating appropriate and timely clinical interventions, thereby providing a better quality of life.

Keywords: Cerebral palsy, hematological parameters, biochemical investigations, anemia, alkaline phosphatase

DOI: 10.3233/PRM-201514

Journal: Journal of Pediatric Rehabilitation Medicine, vol. 16, no. 1, pp. 171-177, 2023