Affiliations: Departments of Neurosurgery, Sanjay Gandhi
Postgraduate Institute of Medical Sciences and C.S.M. Medical University,
India | Departments of Neuroanaesthesiology, Sanjay Gandhi
Postgraduate Institute of Medical Sciences and C.S.M. Medical University,
India | Departments of Medical Genetics, Sanjay Gandhi
Postgraduate Institute of Medical Sciences and C.S.M. Medical University,
India | Departments of Pathology, Sanjay Gandhi Postgraduate
Institute of Medical Sciences and C.S.M. Medical University, India
Note: [] Correspondence: Dr. Raj Kumar, Associate Professor, Department
of Neurosurgery Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow - 226014, U.P., India. Tel: 0 522-668700, 668800; fax: 91 (522) 668129;
E-mail: rajkumar@sgpgi.ac.in
Abstract: An 11-year-old neutropenic female child with acute lymphoblastic
leukemia (ALL) developed a large right frontal mass a month following the
induction of chemotherapy. A well encapsulated mass on surgical excision turned
out to be aspergilloma with metastatic infiltration in frontal lobe. A genetic
defect in form of microsatellite instability was also demonstrated in frontal
mass. A possibility of fungal granuloma in a neutropenic child treated for ALL
(on chemotherapy) remained strong on clinico-radiological evaluation. However,
the cranial involvement in ALL also amounts to be 50 to 80% in untreated
children. The child under discussion had a rare manifestation of both leukemic
infiltration and fungal granuloma formation. Though the microsatellite
instability was demonstrated in the mass, but further genetic studies would be
required to establish the role of genetic defect in evolution of such cerebral
masses/leukemic deposits. (J Pediatr Neurol 2004; 2(1): 39–43).
