Affiliations: Department of Biology, Medical School, Qingdao
University, Qingdao, China | Department of Psychiatry, Medical College, Qingdao
University, Qingdao, China | Shandong Provincial Key Laboratory of Metabolic
Disease, Affiliated Hospital of Medical College, Qingdao University, Qingdao,
China | Institute of Clinical Research, the Affiliated
Hospital of Medical College, Qingdao University, Qingdao, China | Genetic Laboratory, the Affiliated Hospital of Medical
College, Qingdao University, Qingdao, China
Note: [] Corresponding author: Dr. Shiguo Liu, The Affiliated Hospital of
Medical College, Qingdao University, 16, Jiangsu Road, Qingdao, 266003, China.
Tel.: +86 53281912912; Fax: +86 53281912916; E-mail: lsgpumc@126.com
Abstract: The purpose of this study was to investigate the association between
MCP-1 –2518G/A polymorphism and Tourette syndrome (TS) in Chinese Han
population. We collected 324 Chinese Han individuals from 108 TS nuclear
families from Chinese Han population and employed polymerase chain reaction and
restriction enzyme digestion for determining the genotype of MCP-1
–2518G/A polymorphism. The data were analyzed using the transmission
disequilibrium test, the genotype haplotype relative risk and haplotype-based
haplotype relative risk. No biases were observed in the transmission of either
of the two alleles (χ 2=0.016, df=1, P=0.898) to the affected probands in
the total sample. The analyses of transmission disequilibrium test, haplotype
relative risk and haplotype-based haplotype relative risk did not indicate any
associations at MCP-1 –2518G/A with TS. Our results suggest that MCP-1
–2518G/A is not associated with susceptibility of Tourette syndrome in
Chinese Han population.
