Affiliations: Division of Pediatric Neurology, Department of
Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI,
USA | Division of Pediatric Neurology, The Children's
Hospital of Philadelphia, University of Pennsylvania School of Medicine,
Philadelphia, PA, USA
Note: [] Correspondence: Dr. Renée Shellhaas, L3215 Women's
Hospital, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-5203, USA. Tel.: +1
734 936 4179; Fax: +1 734 763 7551; E-mail: shellhaa@med.umich.edu
Abstract: Stroke is more common in the newborn period than at any other time
in childhood and carries the risk of significant long-term neurodevelopmental
morbidity. Arterial ischemic stroke may present acutely in the neonatal period,
or may come to attention later when the child develops a hemiparesis or
symptomatic epilepsy syndrome. Case-control and hospital-based cohort studies
have revealed many factors associated with arterial ischemic perinatal stroke
(IPS), including congenital heart disease, placental pathology, and
thrombophilia. Since both motor and cognitive abnormalities may result,
supportive care of the individual with arterial IPS requires a
multidisciplinary approach and must extend beyond the acute illness phase.
Herein we review the epidemiology, presentation, risk factors, suggested
diagnostic approach, treatment, and outcomes of arterial IPS.
