Affiliations: Department of Pediatrics, Nippon Medical School Tama
Nagayama Hospital, Tokyo, Japan | College of Pharmacy, Nihon University, Funabashi,
Japan | Department of Pharmacy, Nippon Medical School, Tokyo,
Japan
Note: [] Correspondence: Dr. Yasuhiko Kawakami, Department of
Pediatrics, Nippon Medical School Tama Nagayama, Hospital, 1-7-1, Nagayama,
Tama-city, Tokyo 216-8512, Japan. Tel.: +81 42 371 2111; Fax: +81 42 372 7377;
E-mail: kawakami@nms.ac.jp
Abstract: For the treatment of prolonged seizures in children, the use of
diazepam is well established. Flunitrazepam, a benzodiazepine derivative like
diazepam, has also been reported to relieve prolonged seizures. In this study,
the effectiveness of intravenous flunitrazepam administration for prolonged
seizures was clinically examined, and in some patients, the time course of the
serum flunitrazepam concentration was determined. Flunitrazepam appeared to be
clinically effective and safe for prolonged seizures. The time course of serum
flunitrazepam concentration was as previously reported. In this study, we
suggest that intravenous flunitrazepam administration is effective for
prolonged seizures.
