Affiliations: Neuroscience Institute at Shands Jacksonville,
University of Florida College of Medicine, Jacksonville, FL, USA
Note: [] Correspondence: Dr. Juan G. Ochoa, M.D., 580 West 8th Street,
Tower I, 9th Floor, Jacksonville, 32209 FL, USA. Tel.: +1 904 244 9843; Fax: +1
904 2449493; E-mail: juan.ochoa@jax.ufl.edu
Abstract: Experimental studies in animals have suggested that alteration of
extracellular volume, ion concentration and osmolarity may affect the epileptic
process. We report persistent beneficial effects of add-on oral electrolyte
therapy (OET) in seven children with uncontrolled epilepsy. Three patients
treated with OET remained seizure free, one patient became free of absence
seizures but persisted with generalized convulsions and two other patients had
improved seizure control. One patient did not improve and discontinued
treatment after 3 weeks. No significant side effects or complications were
observed. Rice-based OET, used alone or in addition to standard antiepileptic
drugs, may provide a therapeutic effect in children with uncontrolled epilepsy.
Larger controlled studies are needed to validate this finding.