Affiliations: Department of Pediatric Neurology, Queen's Medical
Centre, Nottingham, UK | Department of Pediatric Neurology, Children's
Hospital, Sheffield, UK | Department of Neuroradiology, Queen's Medical Centre,
Nottingham, UK | Department of Neuroradiology, Children's Hospital,
Sheffield, UK | Academic Division of Child Health, University of
Nottingham, Nottingham, UK
Note: [] Correspondence: Dr. Santosh R. Mordekar, Consultant Pediatric
Neurologist, Ryegate Children's Centre, Tapton Crescent, Sheffield S10 5RS, UK.
Tel.: +44 114 2260675; Fax: +44 114 2678296; E-mail:
santosh.mordekar@sch.nhs.uk
Abstract: Acute disseminated encephalomyelitis is an acute demyelinating
disorder of the central nervous system, characterized by an encephalopathy,
multifocal grey matter and white matter involvement. Pediatric high-grade
gliomas represent a heterogeneous group of tumors accounting for 15–20% of
all pediatric brain tumors. We describe two children who were incorrectly
diagnosed as acute disseminated encephalomyelitis initially, but subsequently
found to have glioblastoma multiforme. The cases would exemplify the diagnostic
difficulties in acute disseminated encephalomyelitis.
