Affiliations: Institute of Diagnostic and Interventional Radiology,
Friedrich-Schiller-University Jena, Germany | Department of Radiology, Kirikkale Yuksek Ihtisas
Hospital, Kirikkale, Turkiye | Department of Pediatric Neurology,
Friedrich-Schiller-University Jena, Germany
Note: [] Correspondence: Hans-Joachim Mentzel, MD, Department of
Pediatric Radiology, Institute of Diagnostic and Interventional Radiology,
Friedrich-Schiller-University, Bachstraße 18, D- 07740 Jena, Germany. Tel.:
+49 3641 935358; Fax: +49 3641 936767; E-mail:
hans-joachim.mentzel@med.uni-jena.de
Abstract: To evaluate by means of diffusion tensor magnetic resonance imaging
(DTI) if changes in apparent diffusion coefficient (ADC) and diffusion tensor
fraction anisotropy (FA) in unidentified bright objects (UBOs) and perilesional
normal appearing brain regions of children with neurofibromatosis type 1 (NF1)
can be observed. Ten children with NF1 underwent conventional magnetic
resonance imaging and DTI. The ADC and FA in UBOs and perilesional normal
appearing brain of NF1 patients were compared with the same regions of the
brain of controls. The ADC increased significantly for UBOs and surrounding
normal appearing brain tissue of the brain in children with NF1. We observed no
significant differences in FA between the UBOs and perilesional areas or that
of controls. Although there is limited neuropathologic information about UBOs,
detection of diffusion properties of UBOs can be used to understand tissue
characteristics of UBOs, noninvasively.
