Relevance of the blood-brain barrier on compartmental pharmacokinetics of paracetamol

Article type: Research Article

Authors: Allegaert, Karel | Devlieger, Hugo

Affiliations: Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital, Gasthuisberg, Leuven, Belgium

Note: [] Correspondence: Karel Allegaert, MD, Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital, Gasthuisberg, Leuven, Belgium. Tel.: +32 16 343850; Fax: +32 16 343209; E-mail: karel.allegaert@uz.kuleuven.ac.be

Abstract: Cerebrospinal fluid and plasma pharmacokinetics of paracetamol in one full term neonate are described. The observed impact of the blood-brain barrier of paracetamol on the compartmental pharmacokinetics and the pharmacodynamic relevance of this observation are discussed.

Keywords: Paracetamol, pharmacokinetics, pharmacodynamics, analgesia

Journal: Journal of Pediatric Neurology, vol. 3, no. 4, pp. 273-275, 2005