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Inhaled nitric oxide and sildenafil therapy for a pediatric patient with multiple pulmonary arteriovenous malformations

Article type: Other

Authors: Pantaleoni, Julie | Parsapour, Kourosh | Kon, Alexander A.;

Affiliations: Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA | Department of Pediatric Critical Care Medicine University of California, Irvine School of Medicine, Irvine, CA, USA | Pediatric Intensive Care Unit, Naval Medical Center San Diego and University of California, San Diego School of Medicine, San Diego, CA, USA

Note: [] Corresponding author: Alexander A. Kon, MD, FAAP, FCCM, Director, Pediatric Intensive Care Unit, Naval Medical Center San Diego, 34800 BobWilson Drive, San Diego, CA 92134, USA. E-mail: Alexander.Kon@med.navy.mil.

Keywords: Arteriovenous malformations, nitric oxide, phosphodiesterase-5 inhibitors

DOI: 10.3233/PIC-13065

Journal: Journal of Pediatric Intensive Care, vol. 2, no. 4, pp. 181-185, 2013

Received 30 June 2013
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Revision received 29 September 2013
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Accepted 10 October 2013
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Published: 2013
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Abstract

Pulmonary arteriovenous malformations may result in intrapulmonary shunting and hypoxemia, and often are treated by embolization or surgical resection. Previous reports have demonstrated effective treatment of hypoxia with inhaled nitric oxide in the acute setting. In this report, we describe a child with severe hypoxemia secondary to an inoperable pulmonary arteriovenous malformation that was initially managed with the use of nitric oxide followed by long term management with the phosphodiesterase-5 inhibitor, sildenafil.