Invasive community-acquired methicillin-resistant
Staphylococcus aureus infection causing bacteremia and
osteomyelitis simultaneously in two Saudi siblings
Affiliations: Department of Pediatrics, Ras Tanura Health Center,
Saudi Aramco Medical Services Organization, Saudi Arabia
Note: [] Correspondence: Dr. Mathew P. Cherian, Saudi Aramco PO Box
1356, Ras Tanura, 31311, Saudi Arabia. Tel.: +966 3678 4822; Fax: +966 3678
4466; E-mail: mathew.cherian@aramco.com
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has been
now recognized as major pathogen in adults and children, causing a variety of
infections including osteomyelitis. Deep venous thrombosis in children with
S. aureus osteomyelitis occurs rarely. Two siblings of a Saudi family who
acquired MRSA bacteremia and osteomyelitis concurrently are described in this
report. The second patient had an invasive infection characterized by
bacteremia, multifocal osteomyelitis and septic arthritis complicated by deep
venous thrombosis of the left popliteal vein, necessitating anticoagulant
treatment with heparin. To my best knowledge, such simultaneous occurrence of
MRSA bacteremia and osteomyelitis affecting two family members has not been
reported. Also, deep venous thrombosis complicating osteomyelitis is rare and
has not been reported from this region of the world.
Keywords: MRSA, community-acquired, bacteremia, osteomyelitis, deep venous thrombosis