Affiliations: Departments of Pediatrics, Institute of Medical
Sciences, Banaras Hindu University, Varanasi, India | Departments of Endocrinology and Metabolism, Institute
of Medical Sciences, Banaras Hindu University, Varanasi, India | Departments of Biochemistry, Institute of Medical
Sciences, Banaras Hindu University, Varanasi, India
Note: [] Corresponding author: Dr. Rajniti Prasad, Department of
Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi
221 005, India. Tel.: +91 542 2367677; Fax: +91 542 2367568; E-mail: rajnitip@gmail.com
Abstract: The present study was carried out prospectively to evaluate serum
lipids and lipoprotein(a) levels in children with nephrotic syndrome during the
active phase of disease and during a remission. Serum lipids and lipoprotein(a)
levels were measured in 40 children, aged 2–10 years, during the active phase
of nephrotic syndrome; 25 with a first attack, 9 infrequent relapsers and 6
frequent relapsers, and during remission and in 20 healthy age-matched
controls. The mean serum lipids and lipoprotein(a) levels were significantly
raised during the active phase of nephrotic syndrome (p<
0.001). The values were relatively higher in relapsers. The lipids and
lipoprotein(a) levels decreased during a remission but were significantly
higher (p< 0.05) than controls. Serum lipids had a negative
correlation with serum albumin and lipoprotein(a) had a positive correlation
with proteinuria (r=0.5246, p< 0.01) but
no correlation with serum albumin. The elevated lipids and lipoprotein(a) in
both the active phase of nephrotic syndrome and during remission suggest a
possible predisposition to atherosclerosis in future.
