Affiliations: Department of Physical Education, College of Sports
Science, Dong-A University, Busan, Korea
Note: [] Correspondence: Sunghwun Kang, PhD, Department of Physical
Education, College of Sport Sciences, Dong-A University, Busan, 604714, Korea.
Tel.: +82 51 200 7808; Fax: +82 51 200 7805; E-mail: 94psycho@naver.com
Abstract: We investigated whether alterations in autonomic nervous system
(ANS) activity were associated with metabolic. Ten type 1 diabetic children
(11.8 ± 0.8 yr) and ten healthy children (10.7
± 0.4 yr) were evaluated for this study. Fourier
pulsatility index (PI, Doppler ultrasound signa blood flow using by the Doppler
ultrasound signal, clinical features including anthropometric parameters, blood
pressure, and biochemical blood profiles including lipid metabolism were
measured. The ANS activities were assessed by the means of heart rate
variability (HRV) power spectral analysis, which detects the following
frequency components: very low-frequency (VLF) reflecting thermogenic
sympathetic function; low-frequency (LF), an indicator of sympatho-vagal
activity; high-frequency (HF) reflecting parasympathetic activity exclusively;
and total power (TOTAL) representing overall ANS activity. All ANS activities
including thermogenic sympathetic activity were significantly decreased in
children with type 1 diabetes mellitus (T1DM) in comparison to control children
(Total power, p < 0.01; LF, p < 0.01; HF,
p < 0.05 and VLF, p < 0.01). Triglyceride
(TG) and TG/HDL-C levels of atherogenic risk profiles were also significantly
increased in T1DM children (p < 0.01 and p
< 0.05, respectively). However, Fourier pulsatility index (PI) and
blood flow velocity (FLOW) did not show any significant difference between
groups. It was concluded that T1DM children might possess significantly lower
ANS activities with elevated atherogenic risk factors in comparison with normal
children even at the early stage of life. Therefore, it should consider
therapies that can reduce these risk factors causing diabetic complications in
childhood.
