Affiliations: [a]
Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark
| [b] Department of Neurology, University Hospital Cologne, Cologne, Germany
| [c]
Aarhus University Hospital, Department of Neurology, Aarhus, Denmark
Correspondence:
[*]
Correspondence to: Tatyana D. Fedorova, Department of Nuclear Medicine and PET Centre, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Tel.: +45 28443588; E-mail: tdf@clin.au.dk.
Abstract: Isolated REM sleep behaviour disorder (iRBD) is a predictive marker of prodromal Lewy body disease. iRBD prevalence in the general population is around 1%, but it remains under-diagnosed, even though symptoms are alleviated by medication. We developed a population screening strategy and identified 16 iRBD patients by conducting telephone interviews and polysomnography examinations. We compared our population-screened cohort with sleep-center referred patients and found higher MoCA scores and lower MDS-UPDRS-III scores in our patients. In conclusion, screening can be used to identify iRBD patients in a cost-effective manner with the benefit of identifying patients at a very early disease stage.
Keywords: REM sleep behavior disorder, Lewy body disease, Parkinson’s disease, screening, polysomnography
