Digital Biomarkers of Mobility in Parkinson’s Disease During Daily Living

Article type: Research Article

Authors: Shah, Vrutangkumar V.^a | McNames, James^{b; c} | Mancini, Martina^a | Carlson-Kuhta, Patricia^a | Nutt, John G.^a | El-Gohary, Mahmoud^c | Lapidus, Jodi A.^d | Horak, Fay B.^{a; c; *} | Curtze, Carolin^{a; e}

Affiliations: [a] Department of Neurology, Oregon Health & Science University, Portland, OR, USA | [b] Department of Electrical and Computer Engineering, Portland State University, Portland, OR, USA | [c] APDM, Inc., Portland, OR, USA | [d] School of Public Health, Oregon Health & Science University–Portland State University, Portland, OR, USA | [e] Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA

Correspondence: [*] Correspondence to: Fay B. Horak, PhD, Department of Neurology, Oregon Health & Science University, 3181 Sam Jackson Park Road, Portland, OR 97239-3098, USA. Tel.: +1 503 704 3988; E-mail: horakf@ohsu.edu.

Abstract: Background:Identifying digital biomarkers of mobility is important for clinical trials in Parkinson’s disease (PD). Objective:To determine which digital outcome measures of mobility discriminate mobility in people with PD from healthy control (HC) subjects over a week of continuous monitoring. Methods:We recruited 29 people with PD, and 27 age-matched HC subjects. Subjects were asked to wear three inertial sensors (Opal by APDM) attached to both feet and to the lumbar region, and a subset of subjects also wore two wrist sensors, for a week of continuous monitoring. We derived 43 digital outcome measures of mobility grouped into five domains. An Area Under Curve (AUC) was calculated for each digital outcome measures of mobility, and logistic regression employing a ‘best subsets selection strategy’ was used to find combinations of measures that discriminated mobility in PD from HC. Results:Duration of recordings was 66±14 hours in the PD and 59±16 hours in the HC. Out of a total of 43 digital outcome measures of mobility, we found six digital outcome measures of mobility with AUC > 0.80. Turn angle (AUC = 0.89, 95% CI: 0.79–0.97) and swing time variability (AUC = 0.87, 95% CI: 0.75–0.96) were the most discriminative individual measures. Turning measures were most consistently selected via the best subsets strategy to discriminate people with PD from HC, followed by gait variability measures. Conclusion:Clinical studies and clinical practice with digital biomarkers of daily life mobility in PD should include turning and variability measures.

Keywords: Parkinson’s disease, digital outcome measures of mobility, inertial sensors, biomarkers, continuous monitoring

DOI: 10.3233/JPD-201914

Journal: Journal of Parkinson's Disease, vol. 10, no. 3, pp. 1099-1111, 2020