Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Jia, Chunsonga; 1 | Cui, Xina; 1 | Yoshimura, Naokib; c | Mao, Weid | Xu, Erhed | Wang, Qia | Ou, Tongwena; *
Affiliations: [a] Department of Urology, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China | [b] Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA | [c] Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA | [d] Department of Neurology, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China
Correspondence: [*] Correspondence to: Tongwen Ou, Department of Urology, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, No 45 Changchunjie Xichengqu, Beijing 100053, China. Tel.: +86 10 83198899 8447; E-mail: outongwen67@163.com.
Note: [1] These authors contributed equally to this work.
Abstract: Background:Urinary dysfunction is common in Parkinson’s disease (PD) patients and management options are limited. Objective:This study aimed to explore the management of urinary dysfunction by researching the special needs of PD patients. Methods:PD patients with urinary dysfunction who underwent urodynamic testing were recruited from a single center from October 2013 to February 2019. The urinary symptoms, International Prostate Symptom Score and Hoehn–Yahr scale were evaluated. Management was made at the urologists’ discretion with follow-up after three weeks. Urinary symptoms, urodynamics and the management of urinary dysfunction were analyzed. Results:A total of 187 patients with a median age of 66.2 and Hoehn-Yahr scale soccer of 2 were enrolled. Irritative symptoms were more common than obstructive symptoms, while obstructive symptoms were more common in male than female patients, except for incomplete voiding. There were 51% cases of detrusor overactivity, followed by 33% with bladder outlet obstruction, 13% had normal function, 12% had detrusor underactivity, 9% had stress incontinence, 7% had increased bladder sensation and 4% had an acontractile bladder. Tolterodine and tamsulosin were the most common therapeutic agents, respectively prescribed to 38.5% and 27.3% of the patients. Other treatments included catheterization, botulinum toxin A bladder wall injection, transurethral resection of the prostate and urethral dilatation. Urinary symptoms were improved significantly in 74.5% of the patients (p < 0.001), including 27 patients treated with tamsulosin only and 54 patients with tolterodine only. Conclusions:Urinary symptoms and urodynamics were highly variable in PD patients, indicating that most patients may benefit from personalized management.
Keywords: Parkinson’s disease, urinary dysfunction, urodynamics, management
DOI: 10.3233/JPD-191806
Journal: Journal of Parkinson's Disease, vol. 10, no. 3, pp. 993-1001, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl