Autonomic Sweat Responses in REM Sleep Behavior Disorder and Parkinsonism

Article type: Research Article

Authors: Al-Qassabi, Ahmed^{a; b} | Pelletier, Amélie^{c; d} | Fereshtehnejad, Seyed-Mohammad^{a; e} | Postuma, Ronald B.^{a; d; *}

Affiliations: [a] Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada | [b] College of Medicine, Sultan Qaboos University, Muscat, Oman | [c] Department of Neurology, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Québec, Canada | [d] Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cæur de Montréal Montreal, QC, Canada | [e] Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden

Correspondence: [*] Correspondence to: Ronald B. Postuma, MD, MSc, Department of Neurology, L7-305 Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC, H3G 1A4, Canada. Tel.: +1 514 934 8026; Fax: +1 514 934 8265; E-mail: ron.postuma@mcgill.ca.

Abstract: Background:Autonomic dysfunctions including sudomotor abnormalities commonly occur in early Parkinson’s disease (PD), but little is known about potential sudomotor abnormalities in idiopathic REM Sleep Behavior Disorder (iRBD), a strong prodromal marker of PD. Objective:Our aim was to assess sudomotor dysfunction by galvanic skin response using SudoScan, as well as other autonomic markers in 49 iRBD, 40 PD (21 with RBD, 19 without), 20 atypical parkinsonisms, and 41 age-matched controls. Methods:All subjects underwent SudoScan of their hands and feet, a 30-second electrocardiogram with assessment of beat-to-beat variability, assessment of orthostatic blood pressure changes and autonomic symptom questionnaires. Results:The galvanic skin response in the hands of PD patients with RBD was significantly smaller than controls (hand mean difference = –7.877, 95% CI (–13.283, –2.470), p-value = 0.004) and PD patients without RBD (hand mean difference = –9.578, 95% CI (–17.215, –1.941), p-value = 0.014). iRBD and atypical parkinsonism did not have different SudoScan profiles than controls. Conclusions:Galvanic skin responses, as measured by SudoScan did not demonstrate significant sudomotor dysfunction in iRBD, but decreases were seen in the PD subtype associated with RBD.

Keywords: SudoScan, iRBD, Parkinson’s disease, autonomic, galvanic skin response

DOI: 10.3233/JPD-181357

Journal: Journal of Parkinson's Disease, vol. 8, no. 3, pp. 463-468, 2018