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Quality of Life and Mild Cognitive Impairment in Early Parkinson’s Disease: Does Subtype Matter?

Article type: Short Communication

Authors: Lawson, Rachael A.a; * | Yarnall, Alison J.a | Duncan, Gordon W.a | Khoo, Tien K.b | Breen, David P.c | Barker, Roger A.c | Collerton, Daniela | Taylor, John-Paula | Burn, David J.a

Affiliations: [a] Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK | [b] Griffith Health Institute & School of Medicine, Griffith University, Gold Coast, Australia | [c] John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK

Correspondence: [*] Correspondence to: Rachael A Lawson, Clinical Ageing Research Unit, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK. Tel.: +44 191 208 1277; Fax: +44 191 208 1251; E-mail: rachael.lawson@ncl.ac.uk

Keywords: Parkinson’s disease, quality of life, mild cognitive impairment, subtypes

DOI: 10.3233/JPD-140390

Journal: Journal of Parkinson's Disease, vol. 4, no. 3, pp. 331-336, 2014

Published: 2014
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Abstract

We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson’s disease (PD) patients without dementia. Participants completed neuropsychological tests of attention, executive function, visuospatial function, memory, and language, and reported QoL using the Parkinson’s Disease Questionnaire. Impairments were most common in executive function, memory and attention. MCI subtypes were classified according to Movement Disorder Society Task Force criteria. More severe cognitive impairment was associated with poorer quality of life (p = 0.01), but subtype of impairment was not (p > 0.10), suggesting that the nature of cognitive impairment is less significant than its severity.

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