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Article type: Research Article
Authors: Lebouvier, Thibaud; ; ; ; | Pouclet, Hélène; ; ; ; | Coron, Emmanuel; ; ; | Drouard, Anne; | N'Guyen, Jean-Michel | Roy, Monica | Vavasseur, Fabienne | Bruley des Varannes, Stanislas; ; ; | Damier, Philippe; ; | Neunlist, Michel; ; ; | Derkinderen, Pascal; ; ; ; | Rouaud, Tiphaine; ; ; ;
Affiliations: Inserm, U913, Nantes, France | Inserm, CIC-04, Nantes, France | University Nantes, Nantes, France | CHU Nantes, Department of Neurology, Nantes, France | CHU Nantes, Institut des Maladies de l'Appareil Digestif, Nantes, France | CHU Nantes, Pôle d'Information Médicale, Évaluation et Santé Publique (PIMESP), Nantes, France
Note: [] Correspondence to: Pascal Derkinderen, Inserm U913, 1 place Alexis Ricordeau, CHU Nantes, 44093 Nantes Cedex 1, France. Tel.: 0033240165205; Fax: 0033240165203; E-mail: derkinderenp@yahoo.fr; pascal.derkinderen@chu-nantes.fr
Abstract: Olfactory dysfunction (OD) and constipation are two frequent and early non-motor features of Parkinson's disease (PD). Colonic PD neuropathology, the putative cause of constipation, can be analyzed and quantified using routine colonic biopsies and parallels disease severity. The present study was aimed at investigating whether the severity of neuropathology in the colon in PD is related to OD. Twenty-six PD patients were included. Colonic neuropathology, i.e., the density of Lewy pathology and the number of submucosal neurons, was unrelated to OD as assessed using the University of Pennsylvania Smell Identification. This suggests that unlike colonic Lewy pathology, OD is unrelated to disease severity.
Keywords: Parkinson's disease, olfactory dysfunction, enteric nervous system, constipation, Lewy neuritis, biopsies
DOI: 10.3233/JPD-2011-11061
Journal: Journal of Parkinson's Disease, vol. 1, no. 4, pp. 389-394, 2011
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