Cerebrospinal Fluid Protein Level and Mechanical Ventilation in Guillain-Barré Syndrome patients

Article type: Research Article

Authors: Davalos, Long^a | Nowacek, Dustin^a | Elsheikh, Bakri^b | Reynolds, Evan L.^a | Maher Stino, Amro^{a; *}

Affiliations: [a] University of Michigan School of Medicine, Department of Neurology, Division of Neuromuscular Medicine, Ann Arbor, MI, USA | [b] Ohio State University Wexner Medical Center, Department of Neurology, Division of Neuromuscular Medicine, Columbus, OH, USA

Correspondence: [*] Correspondence to: Amro Stino, MD, University of Michigan School of Medicine, Department of Neurology, Division of Neuromuscular Medicine, Ann Arbor, MI, 48109, USA. E-mail: amstino@med.umich.edu.

Abstract: The prognostic value of cerebrospinal fluid (CSF) protein in Guillain Barré Syndrome (GBS) is unclear. We aimed to explore the potential association between CSF protein level and mechanical ventilation in GBS. We undertook a retrospective study of GBS patients from January 2000 to November 2019 at the University of Michigan. 94 patients were ultimately included for evaluation. After adjusting for the Erasmus GBS Respiratory Insufficiency Scale (EGRIS), we did not find a significant difference in CSF protein between ventilated and non-ventilated patients. Elevated CSF protein level does not appear to portend an increased likelihood of mechanical ventilation in GBS patients.

Keywords: Guillain-Barré Syndrome, mechanical ventilation, cerebrospinal fluid protein, prognosis

DOI: 10.3233/JND-200581

Journal: Journal of Neuromuscular Diseases, vol. 8, no. 2, pp. 299-303, 2021