Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Case Report
Authors: Watanabe, S.a; * | Manabe, M.b | Miyata, M.b | Naoe, A.a | Suzuki, T.a
Affiliations: [a] Department of Pediatric Surgery, Fujita Health University Hospital, Aichi, Japan | [b] Department of Pediatrics, Fujita Health University Hospital, Aichi, Japan
Correspondence: [*] Address for correspondence: Shunsuke Watanabe, Department of Pediatric Surgery, Fujita Health University Hospital, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi Prefecture 470-1192, Japan. Tel.: +81 562 93 9247, +81 562 93 2323; Fax: +81 562 93 1951; E-mail: watanabe@fujita-hu.ac.jp.
Abstract: BACKGROUND:Disseminated intravascular coagulation (DIC) with Kasabach-Merrit syndrome from a large hepatic hemangioma is life-threatening. We report a case of giant hepatic hemangioma of the newborn with KMS. RESULTS:The patient was born at 37 gestational weeks and 2 days via cesarean section; weight at birth was 2952 g. Congenital duodenal atresia was noted during the fetal period. DIC developed after delivery and a giant liver hemangioma was diagnosed via abdominal CT. The cause of DIC was Kasabach–Merritt syndrome owing to a giant hepatic hemangioma. First, combination therapy of 2 mg/kg/day of prednisolone and 0.2 mg/kg/day of propranolol was initiated form enterostomy. However, the size of the hepatic hemangioma did not alter, as observed via image evaluation. Therefore, 0.3 mg/kg/day of everolimus was administered frorm enterostomy. Subsequently, the size of the hepatic hemangioma was assessed via image evaluation. Although it did not alter, blood flow to the hepatic hemangioma decreased and thrombocytopenia was also suppressed. We performed hepatic lateral segmentectomy, radical operation for duodenal atresia. The pathological diagnosis of the removed tumor was infantile hemangioma. CONCLUSION:We report everolimus may be useful when PSL and propranolol are ineffective.
Keywords: Everolimus, hepatic hemangioma, Kasabach–Merritt syndrome
DOI: 10.3233/NPM-200504
Journal: Journal of Neonatal-Perinatal Medicine, vol. 14, no. 3, pp. 437-440, 2021
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl