Affiliations: [a] Department of Pediatrics, Division of Neonatology, College of Medicine, Univeristy of Kentucky, Lexington, KY, USA
| [b] Department of Surgery, Division of Pediatric Surgery, College of Medicine, University of Kentucky, Lexington, KY, USA
| [c] Department of Pathology, College of Medicine, Univeristy of Kentucky, Lexington KY, USA
Correspondence:
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Address for correspondence: John Daniel, IV, MD, Department of Pediatrics, Division on Neonatology, 138 Leader Avenue, Suite 009, Lexington, KY 40536, USA. Tel.: +1 859 323 1496; E-mail: John.Daniel@uky.edu.
Abstract: Congenital mesoblastic nephroma (CMN) is the most common renal tumor of infancy; however, it occurs infrequently with an incidence of 1 : 125,000. The cellular and classical variants are the most common subtypes of tumors, with a mixed variant occurring infrequently. We describe two cases of mixed variant CMN, which presented within days of each other differing in their clinical behavior. The first case followed a typical course, previously described in the literature, while the other deviated significantly. Traditionally, CMN presents as large abdominal mass in the neonatal period associated with a paraneoplastic syndrome, which can result in hypertension or hypercalcemia. Surgical resection is curative in most cases and long-term prognosis is excellent. Hypertension rarely persists after removal of the tumor, but remained in one of our two patients.
