Affiliations: Department of Neonatology, Faculté de
Médecine, Université de la Méditerranée-Assistance Publique
Hôpitaux de Marseille-Hôpital de La Conception, Marseille, France | Department of Gynecology and Obstetric, Faculté de
Médecine, Université de la Méditerranée-Assistance Publique
Hôpitaux de Marseille-Hôpital de La Conception, Marseille, France | Department of Pediatric Otorhinolaryngology,
Faculté de Médecine, Université de la
Méditerranée-Assistance Publique Hôpitaux de Marseille-Hôpital
de La Timone, Marseille, France
Note: [] Corresponding author: Laurence Fayol, MD, Assistance Publique Hôpitaux de Marseille-Hôpital
de La Conception, Département de
Néonatologie, 147, Boulevard Baille, 13 385 Marseille cedex 05, France.
Tel.: +33 (0) 4 91 38 40 41; Fax: +33 (0) 4 91 38 40 80; E-mail: laurence.fayol@ap-hm.fr
Abstract: We studied the case of a newborn infant with severe congenital
malformations following carbimazole exposure during the early weeks of
pregnancy. The pattern of these malformations – choanal atresia, tetralogy of
Fallot, duodenal atresia, dysmorphic features, and hypothelia – is unusual and
is consistent with methimazole embryopathy.
Keywords: Carbimazole, choanal atresia, duodenal atresia, tetralogy of Fallot, embryopathy
