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Article type: Research Article
Authors: El Raggal, Nehal M. | Mohamed, Maha H. | Atef, Shereen H. | Salem, Fariza A.
Affiliations: Neonatology Unit, Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Note: [] Corresponding author: Maha H. Mohamed, Ain Shams University, Cairo, Egypt. Tel.: +20 105287175; E-mail: mahahassan1971@yahoo.com
Abstract: Background: Vascular endothelial growth factor (VEGF), a known mediator of angiogenesis, stimulates the survival of endothelial cells in newly formed blood vessels. VEGF exerts its effects by binding to two receptors; VEGFR-1 and VEGFR-2. Soluble VEGFR-1 is a potent inhibitor of vascular endothelial growth factor and placental growth factor. Objective: to test the hypothesis that serum concentration of the soluble receptor sVEGF-R1 is increased in infants with intrauterine growth restriction (IUGR) regardless of the underlying cause of IUGR. Study design: Serum samples of 30 IUGR and 20 appropriate for gestational age (AGA) neonates were obtained within the first 24 h of life and kept frozen at −80°C degrees until the time of assays. Concentrations of sVEGFR-1 were measured by the enzyme-linked immunosorbent assay double sandwich method. Regression analysis was performed to test the association of IUGR with sVEGFR-1 after controlling for confounding variables. Results: sVEGFR-1 concentrations in IUGR patients were increased when compared to control. Patients with preeclamptic mothers had increased sVEGFR-1 when compared to patients with non-preeclamptic mothers. The latter had increased concentrations of sVEGFR-1 than control. sVEGFR-1 correlated negatively with birth weight, length and head circumference of the studied neonates. Conclusion: Concentrations of sVEGFR-1 are increased in the serum of IUGR neonates when compared to AGA controls. IUGR and preeclampsia are independently associated with increased sVEGFR-1 concentrations. This phenomenon presumably reflects a predominance of anti-angiogenic mechanisms present in IUGR.
Keywords: IUGR, sVEGFR-1, preterm, appropriate for gestational age, preeclampsia, angiogenesis, hypoxia
DOI: 10.3233/NPM-2009-0065
Journal: Journal of Neonatal-Perinatal Medicine, vol. 2, no. 3, pp. 169-174, 2009
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