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Article type: Research Article
Authors: Duan, Wenbiao; * | Yang, Mingjin | Sun, Weiliang | Xia, Mingmin | Zhu, Hui | Gu, Chijiang | Zhang, Haiqiang
Affiliations: Department of Gastrointestinal Surgery, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China
Correspondence: [*] Corresponding author. Wenbiao Duan, Department of Gastrointestinal Surgery, The Affiliated People’s Hospital of Ningbo University, Ningbo, 315100, Zhejiang, China. E-mail: wbduan@yeah.net.
Abstract: OBJECTIVE: A comprehensive evaluation of studies using DNA microarray datasets for screening and identifying key genes in gastric cancer is the goal of this systematic review and meta-analysis. To better understand the molecular environment associated with stomach cancer, this study aims to provide a quantitative synthesis of findings. PURPOSE: Using DNA microarray databases in a systematic manner, this study aims to analyze gastric cancer (GC) screening and gene identification efforts. Through a literature review spanning 2002–2022, this research aims to identify key genes associated with GC and develop strategies for screening and prognosis based on these findings. METHODS: The following databases were searched extensively: Science Direct, NCKI, Web of Science, Springer, and PubMed. Fifteen studies met the inclusion and exclusion criteria; 10,134 tissues served as controls and 11,724 as GCs. The levels of critical genes, including COL1A1, COL1A2, THBS2, SPP1, SPARC, COL6A3, and COL3A1, were compared in normal and GC tissues. Rev Man 5.3 was used to do the meta-analysis. While applying models with fixed or random effects, 95% confidence intervals and weighted mean differences were computed. RESULTS According to the meta-analysis, GC tissues exhibited substantially elevated levels of important genes when contrasted with the control group. In particular, there were statistically significant increases in COL1A1 (MD = 2.43, 95% CI: 1.84–3.02), COL1A2 (MD = 2.75, 95% CI: 1.09–4.41), THBS2 (MD = 2.54, 95% CI: 1.66–3.41), SPP1 (MD = 3.64, 95% CI: 3.40–3.88), SPARC (MD = 1.57, 95% CI: 0.37–2.77), COL6A3 (MD = 2.31, 95% CI: 2.02–2.60), and COL3A1 (MD = 2.21, 95% CI: 1.59–2.82). CONCLUSIONS: The COL1A1, THBS2, SPP1, COL6A3, and COL3A1 genes were shown to have potential use in germ cell cancer screening and prognosis, according to this research. Clinical assessment and prognosis of heart failure patients may be theoretically supported by the results of this study.
Keywords: DNA microarray database, gastric cancer, key genes, meta-analysis
DOI: 10.3233/JIFS-236416
Journal: Journal of Intelligent & Fuzzy Systems, vol. Pre-press, no. Pre-press, pp. 1-14, 2024
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