Extrapolating meaning from local field potential recordings

Issue title: Extracellular space

Guest editors: Reinoud Maex

Article type: Review Article

Authors: Harris Bozer, Amber L.^{a; *} | Uhelski, Megan L.^b | Li, Ai-Ling^c

Affiliations: [a] Department of Psychological Sciences, Tarleton State University, Stephenville, Texas 76402, USA | [b] Department of Diagnostic & Biological Sciences, University of Minnesota, Minneapolis, Minnesota, 55455, USA | [c] Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana, 47405, USA

Correspondence: [*] Corresponding author. Tel.: + 1 254 968 1994; Fax: + 1 254 968 1991; E-mail: alharris@tarleton.edu.

Abstract: Local field potentials (LFP) reflect the spatially weighted low-frequency activity nearest to a recording electrode. LFP recording is a window to a wide range of cellular activities and has gained increasing attention over recent years. We here review major conceptual issues related to LFP with the goal of creating a resource for non-experts considering implementing LFP into their research. We discuss the cellular activity that constitutes the local field potential; recording techniques, including recommendations and limitations; approaches to analysis of LFP data (with focus on power-banded analyses); and finally we discuss reports of the successful use of LFP in clinical applications.

Keywords: LFP, local field potentials, field potentials, extracellular, electrophysiology

DOI: 10.3233/JIN-170011

Journal: Journal of Integrative Neuroscience, vol. 16, no. 1, pp. 107-126, 2017