Affiliations: [a] Service de Neurologie, Pôle Neurosciences Cliniques, CHU Bordeaux, Bordeaux, France
| [b] Service de Neurophysiologie Clinique, Pôle Neurosciences Cliniques, CHU Bordeaux, France
| [c] Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Université de Bordeaux, France
| [d] CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Université de Bordeaux, France
| [e] Institut des Maladies Neurodégénératives (IMN), Service de Neurologie, CHU Bordeaux, Bordeaux, France
| [f]
Department of Medical Genetics, ‘Centre de Référence Maladies Rares Neurogénétique’, CHU Bordeaux, Bordeaux, France
| [g] Equipe Neurogénétique translationnelle – NRGEN, Univ. Bordeaux, Bordeaux, France
Correspondence:
[*]
Correspondence to: Louis Salaun, Service de Neurologie, Pôle Neurosciences Cliniques, CHU Bordeaux, Place Amélie Raba Léon, 33076 Bordeaux cedex, France. Tel.: (+33) 05.56.79.56.79; E-mail: louisalaun@hotmail.fr.
Abstract: Huntington’s disease (HD) is a rare neurodegenerative disorder with a distinct phenotype, including involuntary movements, cognitive decline, and behavioral disturbances. Sleep disorder include insomnia, increased sleep onset latency, decrease in total sleep time with frequent nocturnal awakenings and excessive daytime sleepiness. Increased sleep motor activities and abnormal nocturnal agitation have been increasingly recognized as an important component affecting negatively the sleep quality. Here, we report a case of an intensification of diurnal choreic movement during the night, notably during REM-sleep in a patient with manifest HD. This case highlights the diversity of nocturnal sleep motor disorders encountered in HD.
