Affiliations: Department of Human Physiology with Community Health,
Vidyasagar University, Midnapore-721 102, West Bengal, India;
E-mail:somenathroy @ hotmail, com
Note: [] Corresponding author
Abstract: Importance of chromium as environmental toxicant is largely due to
impact on the body to produce cellular toxicity. The impact of chromium and
their supplementation with ascorbic acid was studied on plasma membrane of
liver and kidney in male Wistar rats (80 - 100 g body weight). It has been
observed that the intoxication with chromium ( i. p. ) at the dose of 0.8
mg/100g body weight per day for a period of 28 days causes significant increase
in the level of cholesterol and decrease in the level of phospbolipid of both
liver and kidney. The alkaline pbosphatase, total ATPase and Na^+ -K^+ -ATPase
activities were significantly decreased in both liver and kidney after chromium
treatment,except total ATPase activity of kidney. It is suggested that chromium
exposure at the present dose and duration induce for the alterations of
structure and function of both liver and kidney plasma membrane. Ascorbic acid
( i.p. at the dose of 0.5 mg,/100g body weight per day for period of 28 days)
supplementation can reduce these structural changes in the plasma membrane of
liver and kidney. But the functional changes can not be completely replenished
by the ascorbic acid supplementation in response to chromium exposure. So it is
also suggested that ascorbic acid (nutritional antioxidant) is useful free
radical scavenger to restrain the chromium-induced membrane damage.