Emerging evolution trends of application of natural products in Alzheimer’s disease

Article type: Research Article

Authors: Wang, Xuemei^{a; b; 1} | Li, Xueli^{a; c; 1} | Zhang, Lin^d | Guo, Ruirui^{a; b} | Sun, Xinyue^{a; b} | Sun, Rui^{a; b} | Li, Zexin^{a; b} | Wang, Lanlin^{a; b} | Yue, Changwu^{a; b; *} | Lyu, Yuhong^{a; b; *}

Affiliations: [a] Yan’an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan’an University, Yan’an, Shaanxi, China | [b] Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan’an University, Yan’an, Shaanxi, China | [c] Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, Yan’an University, Yan’an, Shaanxi, China | [d] Department of Pharmacy, Shaoxing Hospital, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang, China

Correspondence: [*] Corresponding authors: Yuhong Lyu and Changwu Yue, Yan’an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan’an University, Yan’an 716000, Shaanxi, China. E-mails: yuhonglyu@126.com and changwuyue@126.com.

Note: [1] The two authors contribute equally to this article.

Abstract: The main objective of this review was to explore the research foci and emerging trends of application of natural products in AD from 1990 to 2019 and evaluated publications qualitatively and quantitatively. CiteSpace V. 4.0 was used to identify top authors, journals, institutions, countries, keywords, co-cited articles, and trends and obtain the visual knowledge maps. Results revealed that the USA, People’s Republic of China and India were the major research countries in this field, while the Western Europe and North America were the areas with frequent international cooperation. Moreover, there was a close collaboration between universities and research institutes. The J Alzheimers Dis was the most productive journal. Alzheimers disease, natural product, brain, central nervous system, disease, and oxidative stress are some of the high centrality and high frequency keywords in the co-occurrence analysis; Indicating Alzheimers disease and its pathogenesis and natural product remain the hotspots in the field. This paper provides an insight into the application of natural products in AD, and provides useful information for AD researchers to find potential collaborators and cooperative institutions.

Keywords: Alzheimer’s disease, natural product, CiteSpace, scientometric analysis

DOI: 10.3233/JCM-215870

Journal: Journal of Computational Methods in Sciences and Engineering, vol. 22, no. 2, pp. 649-659, 2022