Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Jiang, Boa; * | Zheng, Shanglia | An, Lijiaa | Guo, Jianlia | Asakawa, Tetsuyab; c; *
Affiliations: [a] School of Life Science and Biotechnology, Dalian University of Technology, Dalian, Liaoning, China | [b] Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Hamamatsu-city, Shizuoka, Japan | [c] Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China
Correspondence: [*] Corresponding author: Bo Jiang., Ph.D., School of Life Science and Biotechnology, Dalian University of Technology, Dalia No. 2 Linggong Road, Ganjingzi District, Liaoning, 116024, China. Tel.: +86 411 84706355; Fax: +86 411 84706355; E-mail: bojiang@dlut.edu.cn and Tetsuya Asakawa, M.D., Ph.D., Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, 1-20-1, Higashi-ku, Hamamatsu-city, Shizuoka, 431-3192, Japan. Tel.: +81 53 435 2283; Fax: +81 53 435 2282; E-mail: asakawat1971@gmail.com.
Abstract: BACKGROUND:Blueberry juice is a common drink for relieving fatigue, but its mechanisms of action are unclear. OBJECTIVE:This study aimed to validate changes in the dopaminergic system, especially changes in dopamine transporter (DAT) levels, in a fatigued state and assess whether such fatigue-related changes can be ameliorated by blueberry juice. METHODS:We investigated the expression of striatal DAT and tyrosine hydroxylase (TH) in mice subjected to a forced swimming fatigue task and subsequently administered blueberry juice (anthocyanin), caffeine, or Red Bull (caffeine + taurine) to assess DAT and TH changes in the nigrostriatal pathway related with fatigue as well as their relief. RESULTS:Striatal DAT and TH expression was downregulated by fatigue and upregulated by treatment with blueberry juice, caffeine, and Red Bull. In addition, DAT and TH expression exhibited positive correlations with fatigue-related motor performance. CONCLUSIONS:We provided evidence of compensatory responses of striatal DAT and TH in the fatigued state, and treatments to relieve fatigue might upregulate the expression of both striatal DAT and TH. Moreover, small amounts of blueberry juice exerted similar effects as large amounts, suggesting that anthocyanin has relatively strong anti-fatigue effects.
Keywords: Fatigue, anthocyanin, tyrosine hydroxylase, dopamine transporter, forced swimming test, blueberry juice
DOI: 10.3233/JBR-180350
Journal: Journal of Berry Research, vol. 9, no. 2, pp. 321-332, 2019
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl