Serum levels of neuron-specific enolase in patients with fibromyalgia syndrome: Correlation with cognitive functions, quality of life and psychological state
Affiliations: Department of Physical Medicine and Rehabilitation, Dicle University Medical School, Diyarbakır, Turkey
Correspondence:
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Corresponding author: İbrahim Batmaz, Department of Physical Medicine and Rehabilitation, Dicle University Medical School, Diyarbakır, Turkey. Tel.: +90 412 248 80 01 4792; Fax: +90 412 248 85 23; E-mail:ibrahimbatmaz82@hotmail.com
Abstract: BACKGROUND: Fibromyalgia syndrome (FMS) is a non-articular
rheumatic disorder of unclear etiology, characterized by widespread body
pain, fatigue and, psychological complaints OBJECTIVES: To investigate the serum levels of neuron-specific
enolase (NSE) in patients with FMS and to evaluate the relationship between
cognitive function, quality of life and psychological state. MATERIALS AND METHODS: Fifty-five female patients diagnosed with
fibromyalgia according to the American College of Rheumatology (ACR)
classification criteria, and 40 healthy female subjects were enrolled in the
study. Life quality scale [(Fibromyalgia Impact Questionnaire (FIQ)],
psychological state (Beck Depression Scale), and cognitive dysfunction (mini
mental test, clock drawing test) scales were used for patients and control
subjects. Serum NSE levels were studied using the ECLIA method. RESULTS: No significant differences were found in the serum NSE
levels between the FMS patients and the control subjects (p> 0.05). Life
quality and psychological state scores were found to be higher in FMS
patients relative to the control group (p< 0.001). However, no
significant differences were detected in cognitive function (p> 0.05).
Significant correlations were not found between the serum NSE levels and
quality of life, psychological state and cognitive functions (p> 0.05). CONCLUSION: No significant difference was determined between the
groups in terms of NSE levels. Further studies, including larger series,
should be carried out to clarify this relationship.
Keywords: Fibromyalgia syndrome, neuron-specific enolase, cognitive dysfunction, quality of life, psychological state
