Affiliations: [a] Development and Regeneration Key Laboratory of Sichuan Province, Department of Pathology and Pathophysiology, Institute of Neuroscience, Chengdu Medical College, Chengdu, China
| [b] School of Clinical Medicine, Chengdu Medical College, Chengdu, China
| [c] Department of General Surgery, Chengdu Second People’s Hospital, Chengdu, China
| [d] School of Laboratory Medicine, Chengdu Medical College, Chengdu, China
Correspondence:
[*]
Correspondence to: Cui Jia and LuShun Zhang, Development and Regeneration Key Laboratory of Sichuan Province, Department of Pathology and Pathophysiology, Institute of Neuroscience, Chengdu Medical College, Chengdu, 610500, China. E-mails: 18280078123@163.com, zhangls2012@cmc.edu.cn.
Note: [1] These authors contributed equally to this work.
Abstract: Background:No effective drugs currently exist to cure Alzheimer’s disease (AD) due to its complexity and the lack of understanding of the involved molecular signaling and pathways. The relationship between liver health and AD is now widely recognized. Still, molecular links and shared pathways between the liver and brain remain unclear, making the liver-brain axis in AD therapies a new area for exploration. However, bibliometric studies on this topic are lacking. Objective:This study aims to review the liver-brain axis in AD and identify future research hotspots and trends through bibliometric analysis. Methods:Articles and reviews related to AD and liver and its related diseases were searched in the Web of Science Core Collection (WoSCC) database up to 2024. Data were processed and visually analyzed using VOSviewer, CiteSpace, and Pajek. Results:We collected 1,777 articles on AD and liver and its related diseases from 2,517 institutions across 80 countries. Keyword cluster analysis identified 11 clusters, with ‘insulin resistance,’ ‘amyloid-beta,’ ‘apolipoprotein-E,’ ‘oxidative stress,’ and ‘inflammation’ appearing most frequently, and exhibiting strong total link strength. These results indicate that these topics have been the primary focus of research on the liver-brain axis in AD. Conclusions:This study is the first to comprehensively analyze the liver-brain axis in AD using bibliometric methods. The research results identify recent research frontiers and hotspots, aiding scholars in gaining a deeper understanding of the correlation between AD and the liver.
