Delaying Brain Aging or Decreasing Tau Levels as Strategies to Prevent Alzheimer’s Disease: In Memoriam of Mark A. Smith

Article type: Short Communication

Authors: Avila, Jesús^{; *}

Affiliations: Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain

Correspondence: [*] Correspondence to: Jesús Avila, Nicolás Cabrera, 1, 28049 Madrid, Spain. Tel.: +34 911964564; E-mail: javila@cbm.cisc.es.

Abstract: Aging is the main risk for neurodegenerative disorders like Alzheimer’s disease. In this short review, I will comment on how delaying brain aging through the addition of Yamanaka Factors or small compounds that bind to the folate receptor alpha, which promote the expression of the Yamanaka Factors or by the decrease tau levels in brain cells from older subjects could serve as strategies to prevent Alzheimer’s disease.

Keywords: Aging, Alzheimer’s disease, tau protein, therapies

DOI: 10.3233/JAD-240500

Journal: Journal of Alzheimer's Disease, vol. 100, no. s1, pp. S265-S270, 2024