Affiliations: [a] Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA
| [b] VA Boston Healthcare System, Boston, MA, USA
| [c] University of California, San Francisco, CA, USA
| [d] San Francisco Veterans Healthcare System, San Francisco, CA, USA
| [e] Northern California Institute for Research and Education, San Francisco, CA, USA
Correspondence:
[*]
Correspondence to: Melanie Arenson, PhD, Boston University Chobanian & Avedisian School of Medicine, 150 S
Huntington Ave, Boston, MA 02130, USA. E-mail: marenson@bu.edu.
Abstract: Background:Black and Hispanic older adults have greater incidence of Alzheimer’s disease and related dementias relative to White adults, but factors underlying these disparities are not well understood, limiting the ability to address them. Objective:To determine the impact of demographics, cardiovascular disease (CVD) and risk factors, social determinants of health (SDOH), and neuropsychiatric risk factors on racial/ethnic disparities in dementia risk among Veterans. Methods:We examined a random sample of 1,579,919 older Veterans (age ≥55) without dementia who received care from the VHA from October 1, 1999 to September 30, 2021. All variables were extracted from national VHA data. We used Cox proportional hazard regression models to examine change in variance in risk of dementia across racial/ethnic groups. Results:During follow up (mean 11.1 years), 13% of Veterans developed dementia. Relative to White Veterans, the adjusted hazard ratios (AHRs) for developing dementia in sex-adjusted models with age as timescale were 1.65 (95% CI, 1.63–1.67) for Black Veterans and 1.50 (95% CI, 1.44–1.56) for Hispanic Veterans. In the model examining CVD and risk factors, AHRs were 1.53 (95% CI, 1.50–1.55) for Black Veterans and 1.38 (95% CI, 1.33–1.44) for Hispanic Veterans. In the model examining SDOH, AHRs were 1.46 (95% CI, 1.43–1.49) for Black Veterans and 1.34 (95% CI, 1.29–1.40) for Hispanic Veterans. Conclusions:SDOH and CVD and risk factors accounted for the greatest amount of variance in racial/ethnic disparities in dementia risk. Cardiovascular disease and SDOH are strong possible targets for interventions designed to reduce these disparities.
Keywords: Alzheimer’s disease, dementia, risk factors, social determinants of
health, Veterans
