Affiliations: [a] Department of Neurology, Baotou Central Hospital, Baotou, China
| [b] Inner Mongolia Autonomous Region Clinical Medical Research Center for Neurological Diseases, Baotou, China
Correspondence:
[*]
Correspondence to: Furu Liang, Department of Neurology, Baotou Central Hospital, Baotou 014040, China. E-mail: ru_liang@sina.com.
Abstract: Background:
Lipids have a significant impact on the development and functioning of the nervous system, but the sex differences between the association of LDL/HDL, which reflects lipid metabolic status, and cognitive impairment remains unclear. Objective:
We aimed to determine if there were sex differences between the association of LDL/HDL and cognitive function in US older adults. Methods:
This population-based cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 and 2013–2014 cycles. The main outcome was poor cognitive performance defined by the Digit Symbol Substitution Test (DSST) < 34 based on published literature. Results:
A total of 1,225 participants were included in the study, with a cognitive impairment incidence of 25.6% (314/1,225). Multivariate regression models demonstrated a significant association between cognitive decline and each 1-unit increase in LDL/HDL, after adjusting for all covariates (adjusted odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.11–1.67). Furthermore, subgroup analysis revealed an interaction between LDL/HDL and cognitive impairment in sex subgroups. Conclusions:
LDL/HDL was associated with cognitive impairment in the US older adult population in adjusted models, although the significance of this association was not observed in females.
Keywords: Alzheimer’s disease, cognition, LDL/HDL cholesterol ratio, National Health and Nutrition Examination Survey (NHANES), older adults, sex differences
