Affiliations: [a] Department of Developmental Psychology, Faculty of Psychology, University of Valencia, Valencia, Spain
| [b] Department of Methodology, Faculty of Psychology, University of Valencia, Valencia, Spain
| [c] Hospital General of Valencia (Spain), Valencia, Spain
| [d] Universidad Jaume I Castellon, Castelló, Spain
| [e] Department of Developmental Psychology, Faculty of Psychology, University of Salamanca, Salamanca, Spain
Correspondence:
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Correspondence to: Juan C. Melendez, Department of Developmental Psychology, Faculty of Psychology, University of Valencia, Av. Blasco Ibañez 21, Valencia 46010, Spain. Tel.: +34 963983844; E-mail: melendez@uv.es; ORCID: 0000-0002-6353-6035.
Abstract: Background:Alzheimer’s disease (AD) stands as the prevailing type of dementia, marked by gradual memory loss and cognitive decline. Transcranial direct current stimulation (tDCS) is a non-invasive method used to regulate cortical brain function and has been explored as a potential treatment for cognitive impairment. Objective:This study aimed to compare the effects of daily home-based active or sham tDCS on cognitive function in patients with early-stage AD and its follow-up after one month. Methods:The study involved a randomized, blinded, and controlled-placebo design, with 18 participants enrolled. The primary outcome measures were general cognitive function, immediate, and delayed recall, and executive function. Participants included in the study were randomly assigned to the anodal and sham tDCS groups. Participants were assessed before and after the intervention and one month after the end of treatment. The home-based intervention was applied for 5 consecutive days, daily. Results:The results showed a significant interaction between the active and sham groups; in particular, improvements in MMSE scores, immediate memory and delayed recall were observed at one-month follow-up in the active group. Conclusions:The positive effects of tDCS on cognitive function in AD patients observed suggest that tDCS may induce long-term neuroplastic changes, leading to sustained improvements in cognitive abilities.
Keywords: Alzheimer’s disease, delayed memory, short-term memory, transcranial direct current stimulation, working memory
