Erratum to: APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid
APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid [Journal of Alzheimer’s Disease, 79 (2021) 511– 530, DOI 10.3233/JAD-200747]
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200747
On page 515 in Table 3; the data from Figure 4 was incorrectly copied into Figure 3, meaning that Figure 3 and 4 have the exact same data numbers in the published article. Below is the correct data for Figure 3.
Table 1
Expression for the Top 20 Peptides and for all complement peptides/proteins by APOE4 copy number in multivariate models accounting for age and gender (Model 1)
| Model 1 | |||||||
| Top 20 Protein/Peptides whose expression differed as function of APOE4 | |||||||
| copy number, controlling for age and gender. | |||||||
| Protein | UniProt ID | Peptide | Log Fold Change | Average Expression | t statistic | P Value | FDR Corrected P Value |
| APOE | P02649 | LGADMEDVR | 3.597 | 9.193 | 28.182 | 0.000 | 0.000 |
| CRP | P02741 | ESDTSYVSLK | – 0.624 | 15.228 | – 4.177 | 0.000 | 0.006 |
| CH3L1 | P36222 | ILGQQVPYATK | 0.136 | 23.114 | 3.926 | 0.000 | 0.008 |
| FABPH | P05413 | SIVTLDGGK | 0.157 | 14.664 | 3.968 | 0.000 | 0.008 |
| CH3L1 | P36222 | SFTLASSETGVGAPISGPGIPGR | 0.133 | 18.225 | 3.800 | 0.000 | 0.010 |
| FABPH | P05413 | SLGVGFATR | 0.133 | 15.706 | 3.775 | 0.000 | 0.010 |
| CH3L1 | P36222 | VTIDSSYDIAK | 0.130 | 21.303 | 3.580 | 0.000 | 0.017 |
| ALDOA | P04075 | ALQASALK | 0.129 | 19.168 | 3.439 | 0.001 | 0.025 |
| APOE | P02649 | CLAVYQAGAR | – 0.691 | 8.715 | – 3.321 | 0.001 | 0.027 |
| APOE | P02649 | LAVYQAGAR | 0.275 | 25.410 | 3.351 | 0.001 | 0.027 |
| APOE | P02649 | LGPLVEQGR | 0.256 | 22.419 | 3.317 | 0.001 | 0.027 |
| ALDOA | P04075 | QLLLTADDR | 0.113 | 16.246 | 3.124 | 0.002 | 0.048 |
| APOE | P02649 | AATVGSLAGQPLQER | 0.222 | 20.145 | 2.835 | 0.005 | 0.111 |
| ENOG | P09104 | GNPTVEVDLYTAK | 0.083 | 11.624 | 2.723 | 0.007 | 0.144 |
| AMBP | P02760 | FLYHK | – 0.142 | 11.800 | – 2.604 | 0.010 | 0.190 |
| KNG1 | P01042 | TVGSDTFYSFK | – 0.156 | 15.118 | – 2.533 | 0.012 | 0.204 |
| PRDX1 | Q06830 | DISLSDYK | 0.088 | 14.604 | 2.533 | 0.012 | 0.204 |
| PRDX2 | P32119 | IGKPAPDFK | 0.208 | 12.992 | 2.514 | 0.012 | 0.204 |
| CFAB | P00751 | VSEADSSNADWVTK | – 0.105 | 16.220 | – 2.440 | 0.015 | 0.229 |
| KPYM | P14618 | LDIDSPPITAR | 0.100 | 18.520 | 2.433 | 0.016 | 0.229 |
| C1QB | P02746 | LEQGENVFLQATDK | – 0.035 | 17.128 | – 1.071 | 0.285 | 0.690 |
| C1QB | P02746 | VPGLYYFTYHASSR | – 0.055 | 17.604 | – 1.215 | 0.225 | 0.643 |
| CFAB | P00751 | DAQYAPGYDK | – 0.117 | 16.401 | – 2.207 | 0.028 | 0.290 |
| CFAB | P00751 | VSEADSSNADWVTK | – 0.105 | 16.220 | – 2.440 | 0.015 | 0.229 |
| CFAB | P00751 | YGLVTYATYPK | – 0.122 | 22.532 | – 2.335 | 0.020 | 0.259 |
| CO2 | P06681 | DFHINLFR | – 0.055 | 18.691 | – 1.086 | 0.279 | 0.690 |
| CO2 | P06681 | HAIILLTDGK | – 0.064 | 15.695 | – 1.540 | 0.125 | 0.542 |
| CO2 | P06681 | SSGQWQTPGATR | – 0.069 | 15.922 | – 1.556 | 0.121 | 0.542 |
| CO3 | P01024 | IHWESASLLR | – 0.206 | 14.006 | – 1.707 | 0.089 | 0.454 |
| CO3 | P01024 | TELRPGETLNVNFLLR | – 0.057 | 10.150 | – 1.448 | 0.149 | 0.590 |
| CO4A | P0C0L4 | DHAVDLIQK | – 0.029 | 22.142 | – 0.591 | 0.555 | 0.891 |
| CO4A | P0C0L4 | GSFEFPVGDAVSK | – 0.024 | 25.297 | – 0.446 | 0.656 | 0.931 |
| CO4A | P0C0L4 | LGQYASPTAK | – 0.031 | 21.701 | – 0.599 | 0.549 | 0.891 |
| CO4A | P0C0L4 | NVNFQK | – 0.013 | 18.387 | – 0.281 | 0.779 | 0.948 |
| CO4A | P0C0L4 | VLSLAQEQVGGSPEK | – 0.037 | 19.989 | – 0.813 | 0.417 | 0.793 |
| CO4A | P0C0L4 | VTASDPLDTLGSEGALSPGGVASLLR | – 0.026 | 18.008 | – 0.650 | 0.516 | 0.868 |
| CO5 | P01031 | DINYVNPVIK | – 0.035 | 16.181 | – 0.512 | 0.609 | 0.908 |
| CO5 | P01031 | TLLPVSKPEIR | – 0.037 | 17.209 | – 0.575 | 0.566 | 0.891 |
| CO5 | P01031 | VFQFLEK | – 0.031 | 18.210 | – 0.481 | 0.631 | 0.917 |
| CO6 | P13671 | ALNHLPLEYNSALYSR | – 0.093 | 16.297 | – 1.515 | 0.131 | 0.550 |
| CO6 | P13671 | SEYGAALAWEK | – 0.098 | 15.760 | – 1.793 | 0.074 | 0.449 |
| CO8B | P07358 | IPGIFELGISSQSDR | – 0.029 | 14.476 | – 0.399 | 0.690 | 0.948 |
| CO8B | P07358 | SDLEVAHYK | – 0.063 | 13.090 | – 1.071 | 0.285 | 0.690 |
| CO8B | P07358 | YEFILK | – 0.052 | 18.883 | – 0.876 | 0.382 | 0.758 |
Log Fold Change - log2 fold change of peptide expression with each additional APOE4 allele copy in multivariate models for all analyzed CSF samples; Average expression – average peptide expression in all analyzed CSF samples; t statistic – hypothesis test statistic estimating the mean peptide expression (population mean) from the sampling distribution for each peptide in all analyzed CSF samples.
