A 19-Year-Old Adolescent with Probable Alzheimer’s Disease¹

Article type: Short Communication

Authors: Jia, Jianping^{a; b; c; d; e; *} | Zhang, Yue^a | Shi, Yuqing^a | Yin, Xuping^a | Wang, Shiyuan^a | Li, Yan^a | Zhao, Tan^a | Liu, Wenying^a | Zhou, Aihong^a | Jia, Longfei^a

Affiliations: [a] Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, P.R. China | [b] Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, P.R. China | [c] Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, P.R. China | [d] Center of Alzheimer’s Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, P.R. China | [e] Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, P.R. China

Correspondence: [*] Correspondence to: Jianping Jia, MD, PhD, Professor of Neurology, Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Changchun Street 45, Xicheng District, Beijing 100053, China. Tel.: +86 10 83199449; E-mail: jjp@ccmu.edu.cn.

Note: [1] This article received a correction notice (Erratum) with the reference: 10.3233/JAD-239001, available at http://doi.org/10.3233/JAD-239001.

Abstract: Alzheimer’s disease (AD) primarily affects older adults. In this report, we present the case of a 19-year-old male with gradual memory decline for 2 years and World Health Organization-University of California Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) results also showing memory impairment. Positron emission tomography-magnetic resonance imaging with 18F fluorodeoxyglucose revealed atrophy of the bilateral hippocampus and hypometabolism in the bilateral temporal lobe. Examination of the patient’s cerebrospinal fluid showed an increased concentration of p-tau181 and a decreased amyloid-β 42/40 ratio. However, through whole-genome sequencing, no known gene mutations were identified. Considering the above, the patient was diagnosed with probable AD.

Keywords: Case report, early-onset Alzheimer’s disease, gene mutation, hippocampal atrophy, memory impairment

DOI: 10.3233/JAD-221065

Journal: Journal of Alzheimer's Disease, vol. 91, no. 3, pp. 915-922, 2023