Psychological Status of the Participants in Alzheimer’s Prevention Initiative Autosomal Dominant Alzheimer’s Disease Colombia

Article type: Research Article

Authors: Ramos, Claudia^{a; b; 1; *} | Madrigal, Claudia^{a; 1} | Aguirre-Acevedo, Daniel Camilo^{a; b} | Giraldo-Chica, Margarita^a | Acosta-Baena, Natalia^a | Aponte, Claudia^a | Aguillón, David^{a; b} | Gómez, Manuela^a | Espinosa, Alejandro^a | Madrigal, Lucia^a | Uribe, Claramonika^a | Saldarriaga, Amanda^a | Alzate, Diana^a | Ruiz, Alejandra^a | Andrade, Angela^a | Lopez, Hugo^a | Langbaum, Jessica B.^c | Sink, Kaycee M.^d | Reiman, Eric M.^c | Tariot, Pierre N.^c | Ríos-Romenets, Silvia^a | Lopera, Francisco^{a; b}

Affiliations: [a] Neuroscience Group of Antioquia, University of Antioquia, Medellin, Colombia | [b] University of Antioquia, Medellin, Colombia | [c] Banner Alzheimer’s Institute, Phoenix, AZ, USA | [d] Genentech Inc., South San Francisco, CA, USA

Correspondence: [*] Correspondence to: Claudia Ramos, MD, Calle 62 No 52-59 Área Asistencial de Neurociencias, Sede de Investigación Universitaria SIU, Postal Code 050010, Medellin, Colombia. Tel.: +57 604 2196424; E-mail: claudia.ramos@gna.org.co.

Note: [1] These authors contributed equally to this work.

Abstract: Background:The SARS-CoV2 global pandemic impacted participants in the Alzheimer’s Prevention Initiative (API) Autosomal Dominant Alzheimer’s Disease (ADAD) clinical trial, who faced three stressors: 1) fear of developing dementia; 2) concerns about missing treatment; and 3) risk of SARS-CoV2 infection. Objective:To describe the frequency of psychological disorders among the participants of the API ADAD Colombia clinical study, treated by a holistic mental health team during the COVID-19 pandemic. The extent of use of mental health team services was explored considering different risk factors, and users and non-users of these services were compared. Methods:Participants had free and optional access to psychology and psychiatry services, outside of the study protocol. Descriptive statistics was used to analyze the frequency of the mental health difficulties. A multivariable logistic regression model has been used to assess associations with using this program. Results:66 participants were treated by the Mental Health Team from March 1, 2020, to December 31, 2020. Before and after the start of the pandemic, the most common psychological problems were anxiety (36.4% before, 63.6% after) and depression (34.8% before, 37.9% after). 70% of users assisted by psychology and 81.6% of those assisted by psychiatry felt that the services were useful for them. Female sex, depression, and anxiety before the pandemic were positively associated with being assisted by either psychology or psychiatry, while the association with hyperlipidemia was negative. Conclusions:A holistic mental health program, carried out in the context of a study, could mitigate psychopathology during pandemics such as COVID-19.

Keywords: Alzheimer’s disease, COVID-19, health services and institutions

DOI: 10.3233/JAD-220941

Journal: Journal of Alzheimer's Disease, vol. 95, no. 3, pp. 1091-1106, 2023