Affiliations: [a]
Department of Psychology, The University of Texas at Austin, Austin, TX, USA
| [b]
Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, TX, USA
| [c]
Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA
Correspondence:
[*]
Correspondence to: Alexandra L. Clark, PhD, 108 East Dean Keeton, SEA 3.234, Austin, TX 78712, USA. Tel.: +1 512 471 1157; E-mail: Alexandra.Clark@austin.utexas.edu.
Note: [1] Data used in preparation of this article were obtained from the HABS-HD database (https://apps.unthsc.edu/itr/researchers). Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073 and R01AG058533. The consent is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Abstract: We examined ethnoracial differences in fatty acid binding protein (FABP)—a family of intracellular lipid carriers—and clarified FABP3 associations with gray and white matter. Relative to Mexican Americans (MAs), FABP3 was higher in Non-Hispanic Whites (NHWS, p < 0.001). Regressions revealed, independent of traditional AD markers, FABP3 was associated with neurodegeneration (B = –0.08, p = 0.003) and WMH burden (B = 0.18, p = 0.03) in MAs, but not in NHWs (ps > 0.18). Findings suggest FABP3 is related to neural health within MAs and highlight its potential as a prognostic marker of brain health in ethnoracially diverse older adults.
