Affiliations: [a] Department of Neurology, Chung-Ang University Gwang-Myeong Hospital, Gwangmyeong, Republic of Korea
| [b] Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Republic of Korea
| [c] Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Republic of Korea
| [d] Department of Radiology and Imaging Sciences, Center for Computational Biology and Bioinformatics, Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA
Correspondence:
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Correspondence to: Young Ho Park, MD, PhD, Department of Neurology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea. Tel.: +82 31 787 7473; Fax: +82 31 787 4059; E-mail: kumimesy@snubh.org.; SangYun Kim, MD, PhD, Department of Neurology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea. Tel.: +82 31 787 7469; Fax: +82 31 787 4059; E-mail: neuroksy@snu.ac.kr.
Abstract: To investigate an association of serum liver enzymes with Alzheimer’s disease (AD) diagnosis and cognitive performance, we performed logistic and linear regression analyses in 781 patients with AD and 405 cognitively normal subjects. We found that alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels had significant positive associations with cognitive performance and were significantly decreased in AD patients. The alkaline phosphatase level and AST to ALT ratio were significantly negatively associated with cognitive performance and were significantly increased in AD patients. This suggests that these liver enzymes might be implicated in the pathogenesis of AD.
