Affiliations:
The Taihu Sanatorium of Jiangsu Province (The Taihu Rehabilitation Hospital of Jiangsu Province), Wuxi, Jiangsu, China
Correspondence:
[*]
Correspondence to: Zhen-Hai Shen, The Taihu Sanatorium of Jiangsu Province (The Taihu Rehabilitation Hospital of Jiangsu Province), No.1 Yuanzhu Road, Binhu District, Wuxi, Jiangsu 214086, China. Tel./Fax: +86 0510 85550121; E-mail: shenzhenhaiszh@126.com.
Note: [1] These authors contributed equally to this work.
Abstract: Background:National and international experts have been attempting to find diagnostic tools for the early identification of symptoms to facilitate early identification and intervention of the disease. Objective:Detection of urine Alzheimer-associated neuronal thread protein (AD7c-NTP) and serum 25-hydroxyvitamin D (25(OH)D) in the diagnosis of Alzheimer’s disease (AD). Methods:Subjects aged >50 years who underwent a physical examination at the Taihu Sanatorium of Jiangsu Province, had no clinical evidence of AD-related issues, and had normal Mini-Mental State Exam and Montreal Cognitive Assessment scores were enrolled in the present study. There were 35 males and 15 females, who were aged 51–91 years. Urine AD7c-NTP levels and serum 25(OH)D concentrations were measured. Results:The Pearson correlation analysis revealed that the urine AD7c-NTP levels in these subjects were negatively correlated with the serum 25(OH)D concentrations (r = –0.460, p < 0.001). Conclusion:Combined with previous studies, it was considered that cognitive function might be the only link for the correlation between AD7c-NTP and 25(OH)D. This finding might provide a starting point to investigate the potential value of the interaction between urine AD7c-NTP and serum 25(OH)D in chronic diseases. Further large-scale studies are needed to validate the results of the present study.
