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Article type: Research Article
Authors: Chen, Ting-Hsianga | Yeh, Yi-Chunb; c | Huang, Mei-Fengb; c; d | Chen, Hui-Meie | Lee, Jia-Inb; c; d | Chen, Cheng-Shengb; c; *
Affiliations: [a] Department of Psychiatry, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan | [b] Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan | [c] Department of Psychiatry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan | [d] Graduated Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan | [e] Department of Occupational Therapy, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan
Correspondence: [*] Correspondence to: Professor Cheng-Sheng Chen, MD, PhD, No. 100, Tzyou 1st Rd, Kaohsiung City, Taiwan. Tel.: +886 7 312 1101/Ext. 6816; Fax: +886 7 3134761; E-mail:sheng@kmu.edu.tw.
Abstract: Background:The Mild Behavioral Impairment Checklist (MBI-C) has been developed to assess mild behavioral impairment (MBI). However, no study has validated the use of MBI-C using a promising translation method in Taiwan. Thus, consistency and discrepancy between informant-rated and self-rated scores have not been extensively researched. Objective:This study validated and compared the informant- and self-rated versions of the MBI-C among community-dwelling people in Taiwan. Method:We recruited 202 pairs of individuals without dementia aged ≥50 years and their cohabitating informants. The participants completed the MBI-C (MBI-C-self), and the informants completed the MBI-C (MBI-C-informant) and the Neuropsychiatric Inventory Questionnaire (NPI-Q) independently. Internal consistency, inter-rater reliability, and convergent validity were examined. Results:Both MBI-C-self and MBI-C-informant exhibited satisfactory Cronbach’s α values (0.92 and 0.88, respectively). The MBI-C-informant total scorewas correlated with the NPI-Q total score (r = 0.83, p < 0.001). Inter-rater reliability between the two versions, as represented by the inter-rater correlation coefficient, was 0.57 (p < 0.001). The prevalence of MBI based on the MBI-C-informant scores was 1.5% higher than that based on the MBI-C-self scores according to the suggested cut-off score of 8.5. The affective dysregulation domain score of MBI-C-informant was significantly lower than that of MBI-C-self. Conclusion:MBI-C-informant exhibited both high reliability and validity. Discrepancies between MBI-C-informant and MBI-C-self related to the detection rates and affective dysregulation domain scores were noted. The level of consistency and discrepancy between these two versions provide implications for the use of MBI-C in clinical practice and future research.
Keywords: Mild behavioral impairment, Mild Behavioral Impairment Checklist, prodromal, validation
DOI: 10.3233/JAD-220006
Journal: Journal of Alzheimer's Disease, vol. 90, no. 3, pp. 1203-1213, 2022
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