Quantifying and Describing the Natural History and Costs of Alzheimer’s Disease and Effects of Hypothetical Interventions
Anders Wimo, Ron Handels, Bengt Winblad, Christopher M. Black, Gunilla Johansson, Stina Salomonsson, Maria Eriksdotter, Rezaul K. Khandker
[Journal of Alzheimer’s Disease 75(3), 2020, 891-902. DOI 10.3233/JAD-191055] https://content.iospress.com/articles/journal-of-alzheimers-disease/jad191055
Because of a data extraction error, a correction is needed.
Instead of reporting 10-20-30-40 years results, figures representing 11-21-31-41 years were reported. There are no errors in the database or in the model and no impact on conclusions.
Correct tables are as below:
Table 1
Main outcomes in the simulated cohort of 100,000 MCI-AD persons after 40 years
| 10 years | 20 years | 30 years | 40 years | |
| Cumulative cases of dementia | 87,752 | 95,433 | 95,952 | 95,969 |
| Cumulative deaths | 13,391 | 52,501 | 93,908 | 99,973 |
| Cumulative deaths with dementia | 10,275 | 48,647 | 89,892 | 95,942 |
| Cumulative deaths with AD-MCI | 3,116 | 3,854 | 4,016 | 4,030 |
| Mean PYs/person | 9.50 | 16.41 | 18.83 | 18.97 |
| Mean Pys/person with dementia | 5.67 | 12.24 | 14.63 | 14.78 |
| Mean Pys/person AD-MCI (without dementia) | 3.84 | 4.17 | 4.20 | 4.20 |
| Mean Pys/person in Mild AD | 2.84 | 4.42 | 4.93 | 4.97 |
| Mean Pys/person in Moderate AD | 2.34 | 5.90 | 7.23 | 7.31 |
| Mean PYs/person in Severe AD | 0.49 | 1.92 | 2.47 | 2.50 |
Table 2
Cumulative cohort cost distribution (state related cumulative costs, SEK) and QALY distribution (state related cumulative) (both NPVs) during the simulated period (1 US$ = 8.56 SEK)
| Severity state | 5 years | 10 years | 20 years | 30 years | 40 years |
| Costs (million SEK) | |||||
| AD-MCI | 55,3188 | 70,918 | 76,421 | 76,760 | 76,771 |
| Mild | 31,6329 | 63,333 | 94,956 | 104,029 | 104,650 |
| Moderate | 15,7287 | 65,716 | 156,962 | 187,754 | 189,440 |
| Severe | 1,6823 | 16,990 | 62,898 | 78,900 | 79,514 |
| Total costs | 104,3627 | 216,957 | 391,238 | 447,443 | 450,375 |
| Cost/PY AD-dementia (SEK) | 249,0394 | 257,756 | 257,221 | 253,310 | 252,843 |
| QALYs | |||||
| AD-MCI | 225,166 | 283,161 | 301,214 | 302,122 | 302,146 |
| Mild | 85,415 | 163,457 | 230,727 | 246,489 | 247,384 |
| Moderate | 20,692 | 80,788 | 174,066 | 199,476 | 200,606 |
| Severe | 1,118 | 10,330 | 33,325 | 39,630 | 39,819 |
| Total QALYs | 332,391 | 537,736 | 739,332 | 787,716 | 789,956 |
Table 4: NNT 10 years: 11, NNT 20 years 28, NNTs 30 and 40 years are correct.
