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Article type: Research Article
Authors: Mayà, Gerarda; 1 | Sarto, Jordia; e; 1 | Compta, Yaroslaua | Balasa, Mirceaa | Ximelis, Teresab | Aldecoa, Ibanb; c | Gelpi, Ellenb; d | Sánchez-Valle, Raquela; b | Molina-Porcel, Lauraa; b; *
Affiliations: [a] Neurology Service-ICN, Hospital Clínic de Barcelona, Barcelona, Spain | [b] Neurological TissueBank of the Biobank-IDIBAPS-Hospital Clínic, Barcelona, Spain | [c] Pathology Service-CDB, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain | [d] Department of Neurology, Division of Neuropathology and Neurochemistry, Medical University of Vienna, Vienna, Austria | [e] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED), Madrid, Spain
Correspondence: [*] Correspondence to: Laura Molina-Porcel, MD, PhD, Neurological Tissue Bank of the Biobank-IDIBAPS-Hospital Clínic, c/ Casanova 143, Ala Sud, Planta 008036 Barcelona, Spain. E-mail: lmolinap@clinic.cat.
Note: [1] These authors contributed equally to this work.
Abstract: Background: For neuroscience research, the study of brain tissue of neurologically unimpaired subjects is crucial to interpret findings in neurodegenerative diseases. Sub-optimal neurological follow-up and the presence of neuropathological lesions in supposedly asymptomatic subjects casts doubt as to whether these subjects present an undetected underlying neurodegenerative disease or are resilient to neurodegeneration. Objective: We aimed to assess whether the control donors registered in the Neurological Tissue Bank-Hospital Clínic-IDIBAPS (NTB-HCI) are still free of cognitive symptoms at follow-up and to evaluate the feasibility and utility of a telephone-based screening. Methods: All control subjects older than 65 years registered at the NTB-HCI database were selected for the study. After a structured telephone interview, those subjects already diagnosed with a neurological disease were excluded. Then, a cognitive screening was performed, including the telephone version of the Mini-Mental State Examination (t-MMSE) and the eight-item interview (AD-8) to the subject and to one informant (AD-8i). Results: In total, 73.8% of the registered donors collaborated in the study. Only 21.4% had at least one of the three cognitive screening tools impaired, and 2.7% had a profile highly suggestive of cognitive impairment. AD-8i correlated moderately with t-MMSE. Conclusion: Telephone-based neurologic screening in control donors is feasible and was within the normal range in most of the subjects in our cohort. Albeit, the involvement of neurologists and periodic neurological screenings are desirable in a control subjects brain donor program, AD8-i could be used to screen the control’s neurological status in the absence of accurate clinical data at the time of the death.
Keywords: AD-8, brain bank, cognitive symptoms, neurological healthy controls, neurological screening, telephone-based screening, telephone MMSE
DOI: 10.3233/JAD-215444
Journal: Journal of Alzheimer's Disease, vol. 85, no. 3, pp. 1107-1113, 2022
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