Affiliations: [a] Department of Pharmacology and Toxicology, The Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA
| [b]
Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA
| [c] Cardiopulmonary and Immunotoxicology Branch, Public Health and Integrated Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA
Correspondence:
[*]
Correspondence to: Michelle L. Block, PhD, Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, NB 214D, Indianapolis, IN 46202, USA. E-mail: mlblock@iupui.edu.
Abstract: The mechanisms underlying how urban air pollution exposure conveys Alzheimer’s disease risk and affects plaque pathology is largely unknown. Because particulate matter, the particle component of urban air pollution, varies across location, pollution source, and time, a single model representative of all ambient particulate matter is unfeasible for research investigating the role of ar pollution in central nervous system diseases. More specifically, the investigation of several models of particulate matter with enrichment of source-specific components are essential to employ, in order to more fully understand what characteristics of particulate matter affects Alzheimer’s disease, including standardized diesel exhaust particles.
