Recent Advances on Possible Association Between the Periodontal Infection of Porphyromonas gingivalis and Central Nervous System Injury

Article type: Review Article

Authors: Yu, Wenlei^{a; b; 1} | Lu, Linjie^{a; b; 1} | Ji, Xintong^{a; b} | Qian, Qiwei^{a; b} | Lin, Xiaohan^a | Wang, Huanhuan^{a; b; *}

Affiliations: [a] School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China | [b] Laboratory of Aging and Cancer Biology of Zhejiang Province, Hangzhou Normal University, Hangzhou, China

Correspondence: [*] Correspondence to: Dr. Huanhuan Wang, School of Basic Medical Sciences, Hangzhou Normal University, Yuhangtang Rd. 2318#, Hangzhou, 311121, China. E-mail: huanval@hznu.edu.cn.

Note: [1] These authors contributed equally to this work.

Abstract: Chronic periodontitis caused by Porphyromonas gingivalis (P. gingivalis) infection generally lasts for a lifetime. The long-term existence and development of P. gingivalis infection gradually aggravate the accumulation of inflammatory signals and toxic substances in the body. Recent evidence has revealed that P. gingivalis infection may be relevant to some central nervous system (CNS) diseases. The current work collects information and tries to explore the possible relationship between P. gingivalis infection and CNS diseases, including the interaction or pathways between peripheral infection and CNS injury, and the underlying neurotoxic mechanisms.

Keywords: Epigenetic regulation, nervous system damage (CNS), neuroinflammation, Porphyromonasgingivalis

DOI: 10.3233/JAD-215143

Journal: Journal of Alzheimer's Disease, vol. 84, no. 1, pp. 51-59, 2021