The Correlation of Tau Levels with Blood Monocyte Count in Patients with Alzheimer’s Disease

Article type: Research Article

Authors: Sun, Hao-Lun^{a; b; 1} | Zhou, Fa-Ying^{a; 1} | Chen, Dong-Wan^a | Tan, Cheng-Rong^a | Zeng, Gui-Hua^a | Liu, Yu-Hui^a | Wang, Jun^a | Bu, Xian-Le^a | Wang, Yan-Jiang^a | Li, Hui-Yun^{a; *} | Jin, Wang-Sheng^{a; *}

Affiliations: [a] Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China | [b] Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Shigatse, China

Correspondence: [*] Correspondence to: Wang-Sheng Jin and Hui-Yun Li, Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. E-mails: skjws123@163.com (Jin); lihuiyun1108@163.com (Li)

Note: [1] These authors contributed equally to this work.

Abstract: Background:Recent studies have shown that monocytes can phagocytize the tau protein, which may ameliorate tau-type pathology in Alzheimer’s disease (AD). However, there are few clinical studies on the relationship between monocytes and tau-type pathology in AD patients. Objective:We aimed to explore changes in peripheral monocytes and their association with tau protein in AD patients. Methods:A total of 127 clinically diagnosed AD patients and 100 age- and sex-matched cognitively normal controls were recruited for analysis of the correlation of plasma tau levels with the blood monocyte count. Cerebrospinal fluid (CSF) samples from 46 AD patients and 88 controls were further collected to analyze the correlation of CSF tau and amyloid-β (Aβ) levels with the blood monocyte count. 105 clinically diagnosed mild cognitive impairment (MCI) patients and 149 age- and sex-matched cognitively normal controls were recruited from another cohort for verification. Results:Compared to normal controls, AD patients showed a significant reduction in the blood monocyte count. In addition, the monocyte count of AD patients was negatively correlated with CSF t-tau and p-tau levels but not with plasma tau levels. In normal people, monocyte count lack correlation with tau levels both in plasma and CSF. Monocyte count were not correlated with CSF Aβ levels in either group but were negatively correlated with CSF tau/Aβ42 levels in the AD group. We had further verified the correlations of monocyte count with CSF tau levels in another cohort. Conclusion:This study suggests that monocytes may play an important role in the clearance of tau protein in the brain.

Keywords: Alzheimer’s disease, monocytes, pathogenesis, tau

DOI: 10.3233/JAD-210692

Journal: Journal of Alzheimer's Disease, vol. 85, no. 3, pp. 1321-1328, 2022