Affiliations: [a]
Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland, UK
| [b]
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, UK
| [c] Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland, UK
| [d]
Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, Scotland, UK
Correspondence:
[*]
Correspondence to: Donald M. Lyall, PhD, 1 Lilybank Gardens, Institute of Health and Wellbeing, University of Glasgow, G12 8RZ, Glasgow, UK. Tel.: +44 0 141 330 8547; Fax: +44 0 141 330 1874; E-mail: Donald.Lyall@Glasgow.ac.uk.
Abstract: Recent research suggests genetic variation in the Klotho locus may modify the association between APOE ɛ4 and cognitive impairment. We tested for associations and interactions between these genotypes versus risk of dementia, cognitive abilities, and brain structure in older UK Biobank participants. Klotho status was indexed with rs9536314 heterozygosity (versus not), in unrelated people with versus without APOE ɛ4 genotype, corrected for various confounders. APOE ɛ4 associated with increased risk of dementia, worse cognitive abilities, and brain structure. Klotho was associated with better reasoning. There were no interactions; potentially suggesting an age- and pathology-dependent Klotho effect.
